Evaluation of Kawasaki disease risk-scoring systems for intravenous immunoglobulin resistance.

ABSTRACT:

Objectives

To assess the performance of 3 risk scores from Japan that were developed to predict, in children with Kawasaki disease, resistance to intravenous immunoglobulin (IVIG) treatment.

Study design

We used data from a randomized trial of pulsed steroids for primary treatment of Kawasaki disease to assess operating characteristics of the 3 risk scores, and we examined whether steroid therapy lowers the risk of coronary artery abnormalities in patients prospectively classified as IVIG resistant.

Results

For comparability with published cohorts, we analyzed the data of 99 patients who were not treated with steroids (16% IVIG-retreated) and identified male sex, lower albumin level, and higher aspartate aminotransferase level as independent risk factors for IVIG resi

SUBMITTER: Sleeper LA 

PROVIDER: S-EPMC3075321 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature