Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
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ABSTRACT:
SUBMITTER: Fukuda A
PROVIDER: S-EPMC3075548 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Fukuda Akihisa A Wang Sam C SC Morris John P JP Folias Alexandra E AE Liou Angela A Kim Grace E GE Akira Shizuo S Boucher Kenneth M KM Firpo Matthew A MA Mulvihill Sean J SJ Hebrok Matthias M
Cancer cell 20110401 4
Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and progression in mouse models of the disease. However, the mechanistic link between inflammatory damage and PDA initiation is unclear. Using a Kras-driven mouse model of PDA, we establish that the inflammatory mediator Stat3 is a critical component of spontaneous and pancreatitis-accelerated PDA precursor formation and supports cell prolife ...[more]
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