Ontology highlight
ABSTRACT:
SUBMITTER: Choi UB
PROVIDER: S-EPMC3075556 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Choi Ucheor B UB McCann James J JJ Weninger Keith R KR Bowen Mark E ME
Structure (London, England : 1993) 20110401 4
Intrinsically disordered proteins (IDPs) participate in critical cellular functions that exploit the flexibility and rapid conformational fluctuations of their native state. Limited information about the native state of IDPs can be gained by the averaging over many heterogeneous molecules that is unavoidable in ensemble approaches. We used single molecule fluorescence to characterize native state conformational dynamics in five synaptic proteins confirmed to be disordered by other techniques. Fo ...[more]