Ontology highlight
ABSTRACT:
SUBMITTER: Martin R
PROVIDER: S-EPMC3075580 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Martin Ronny R Moran Gary P GP Jacobsen Ilse D ID Heyken Antje A Domey Jenny J Sullivan Derek J DJ Kurzai Oliver O Hube Bernhard B
PloS one 20110407 4
The extension of germ tubes into elongated hyphae by Candida albicans is essential for damage of host cells. The C. albicans-specific gene EED1 plays a crucial role in this extension and maintenance of filamentous growth. eed1Δ cells failed to extend germ tubes into long filaments and switched back to yeast growth after 3 h of incubation during growth on plastic surfaces. Expression of EED1 is regulated by the transcription factor Efg1 and ectopic overexpression of EED1 restored filamentation in ...[more]