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In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques.

ABSTRACT: BACKGROUND: Single-walled carbon nanotubes (SWCNT) hold promise for applications as contrast agents and target delivery carriers in the field of nanomedicine. When administered in vivo, their biodistribution and pharmacological profile needs to be fully characterized. The tissue distribution of carbon nanotubes and their potential impact on metabolism depend on their shape, coating, and metallic impurities. Because standard radiolabeled or fluorescently-labeled pharmaceuticals are not well suited for long-term in vivo follow-up of carbon nanotubes, alternative methods are required. METHODS: In this study, noninvasive in vivo magnetic resonance imaging (MRI) investigations combined with high-resolution magic angle spinning (HR-MAS), Raman spectroscopy, iron assays, and histological analysis ex vivo were proposed and applied to assess the biodistribution and biological impact of intravenously injected pristine (raw and purified) and functionalized SWCNT in a 2-week longitudinal study. Iron impurities allowed raw detection of SWCNT in vivo by susceptibility-weighted MRI. RESULTS: A transitional accumulation in the spleen and liver was observed by MRI. Raman spectroscopy, iron assays, and histological findings confirmed the MRI readouts. Moreover, no acute toxicological effect on the liver metabolic profile was observed using the HR-MAS technique, as confirmed by quantitative real-time polymerase chain reaction analysis. CONCLUSION: This study illustrates the potential of noninvasive MRI protocols for longitudinal assessment of the biodistribution of SWCNT with associated intrinsic metal impurities. The same approach can be used for any other magnetically-labeled nanoparticles.

SUBMITTER: Al Faraj A

PROVIDER: S-EPMC3075901 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques.

Al Faraj Achraf A Fauvelle Florence F Luciani Nathalie N Lacroix Ghislaine G Levy Michael M Crémillieux Yannick Y Canet-Soulas Emmanuelle E

International journal of nanomedicine 20110215

<h4>Background</h4>Single-walled carbon nanotubes (SWCNT) hold promise for applications as contrast agents and target delivery carriers in the field of nanomedicine. When administered in vivo, their biodistribution and pharmacological profile needs to be fully characterized. The tissue distribution of carbon nanotubes and their potential impact on metabolism depend on their shape, coating, and metallic impurities. Because standard radiolabeled or fluorescently-labeled pharmaceuticals are not wel ...[more]

PMID: 21499425

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Project description:Abstract Carbon nanotube (CNT) devices and electronics are achieving maturity and directly competing or surpassing devices that use conventional materials. CNTs have demonstrated ballistic conduction, minimal scaling effects, high current capacity, low power requirements, and excellent optical/photonic properties; making them the ideal candidate for a new material to replace conventional materials in next?generation electronic and photonic systems. CNTs also demonstrate high stability and flexibility, allowing them to be used in flexible, printable, and/or biocompatible electronics. However, a major challenge to fully commercialize these devices is the scalable placement of CNTs into desired micro/nanopatterns and architectures to translate the superior properties of CNTs into macroscale devices. Precise and high throughput patterning becomes increasingly difficult at nanoscale resolution, but it is essential to fully realize the benefits of CNTs. The relatively long, high aspect ratio structures of CNTs must be preserved to maintain their functionalities, consequently making them more difficult to pattern than conventional materials like metals and polymers. This review comprehensively explores the recent development of innovative CNT patterning techniques with nanoscale lateral resolution. Each technique is critically analyzed and applications for the nanoscale?resolution approaches are demonstrated. Promising techniques and the challenges ahead for future devices and applications are discussed. Carbon nanotube (CNT) devices are achieving maturity and directly competing with devices using conventional materials. However, a major challenge to fully commercialize is the scalable placement of CNTs into nanoscale patterns/architectures into macroscale devices. This review comprehensively explores the recent development of nanoscale resolution CNT patterning techniques. Each technique is critically analyzed, applications are demonstrated, and challenges/opportunities are discussed.

Dataset Information

In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques.

Publications

In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques.

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