Ontology highlight
ABSTRACT:
SUBMITTER: Kar K
PROVIDER: S-EPMC3075957 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Kar Karunakar K Jayaraman Murali M Sahoo Bankanidhi B Kodali Ravindra R Wetzel Ronald R
Nature structural & molecular biology 20110213 3
Because polyglutamine (polyQ) aggregate formation has been implicated as playing an important role in expanded CAG repeat diseases, it is important to understand the biophysics underlying the initiation of aggregation. Previously, we showed that relatively long polyQ peptides aggregate by nucleated growth polymerization and a monomeric critical nucleus. We show here that over a short range of repeat lengths, from Q(23) to Q(26), the size of the critical nucleus for aggregation increases from mon ...[more]