Ontology highlight
ABSTRACT:
SUBMITTER: Vandanmagsar B
PROVIDER: S-EPMC3076025 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Vandanmagsar Bolormaa B Youm Yun-Hee YH Ravussin Anthony A Galgani Jose E JE Stadler Krisztian K Mynatt Randall L RL Ravussin Eric E Stephens Jacqueline M JM Dixit Vishwa Deep VD
Nature medicine 20110109 2
The emergence of chronic inflammation during obesity in the absence of overt infection or well-defined autoimmune processes is a puzzling phenomenon. The Nod-like receptor (NLR) family of innate immune cell sensors, such as the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (Nlrp3, but also known as Nalp3 or cryopyrin) inflammasome are implicated in recognizing certain nonmicrobial originated 'danger signals' leading to caspase-1 activation and subsequent in ...[more]