Ontology highlight
ABSTRACT:
SUBMITTER: Denmark SE
PROVIDER: S-EPMC3076050 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20101201 1
Marine neuroexcitatory compounds isodomoic acids G and H were efficiently synthesized from a common intermediate using a silicon-based cross-coupling reaction. Dividing each target compound into the core fragment and the side-chain fragment enabled the synthesis to be convergent. The trans-2,3-disubstituted pyrrolidine core fragment was accessed through a diastereoselective rhodium-catalyzed carbonylative silylcarbocyclization reaction of a vinylglycine-derived 1,6-enyne. A stereochemically dive ...[more]