Ontology highlight
ABSTRACT:
SUBMITTER: Huang Z
PROVIDER: S-EPMC3076066 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Huang Zhi Z Wu Qiulian Q Guryanova Olga A OA Cheng Lin L Shou Weinian W Rich Jeremy N JN Bao Shideng S
Nature cell biology 20110123 2
The repressor element 1-silencing transcription factor (REST) functions as a master regulator to maintain neural stem/progenitor cells (NPCs). REST undergoes proteasomal degradation through β-TrCP-mediated ubiquitylation during neuronal differentiation. However, reciprocal mechanisms that stabilize REST in NPCs are undefined. Here we show that the deubiquitylase HAUSP counterbalances REST ubiquitylation and prevents NPC differentiation. HAUSP expression declines concordantly with REST on neurona ...[more]