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Increased peripheral blood expression of electron transport chain genes in bipolar depression.

ABSTRACT: To identify specific genetic pathways showing altered expression in peripheral blood of depressed subjects with bipolar disorder (BPD).? Illumina Sentrix BeadChip (Human-6v2) microarrays containing >48,000 transcript probes were used to measure levels of gene expression in peripheral blood from 20 depressed subjects with BPD and in 15 healthy control subjects. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to confirm a subset of these differences.? A total of 1,180 genes were differentially expressed between subjects with BPD and healthy controls (fold-change >1.3, false discovery rate-corrected p?

SUBMITTER: Beech RD

PROVIDER: S-EPMC3076072 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Increased peripheral blood expression of electron transport chain genes in bipolar depression.

Beech Robert D RD Lowthert Lori L Leffert Janine J JJ Mason Portia N PN Taylor Mary M MM Umlauf Sheila S Lin Aiping A Lee Ji Young JY Maloney Kathleen K Muralidharan Anjana A Lorberg Boris B Zhao Hongyu H Newton Samuel S SS Mane Shrikant S Epperson C Neill CN Sinha Rajita R Blumberg Hilary H Bhagwagar Zubin Z

Bipolar disorders 20101201 8

<h4>Objective</h4> To identify specific genetic pathways showing altered expression in peripheral blood of depressed subjects with bipolar disorder (BPD).<h4>Methods</h4> Illumina Sentrix BeadChip (Human-6v2) microarrays containing >48,000 transcript probes were used to measure levels of gene expression in peripheral blood from 20 depressed subjects with BPD and in 15 healthy control subjects. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to confirm ...[more]

PMID: 21176028

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