Ontology highlight
ABSTRACT:
SUBMITTER: Chiba S
PROVIDER: S-EPMC307610 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Chiba Shigeru S Takeshita Kenichi K Imai Yoichi Y Kumano Keiki K Kurokawa Mineo M Masuda Shigeo S Shimizu Kiyoshi K Nakamura Shuji S Ruddle Frank H FH Hirai Hisamaru H
Proceedings of the National Academy of Sciences of the United States of America 20031211 26
In the transforming growth factor beta (TGF-beta) superfamily, activin A, TGF-beta1, and bone morphogenic protein 4 (BMP-4) have various effects on hematopoiesis, including early mesodermo-hematogenesis. After these cytokines bind to their respective receptor, a regulatory Smad is phosphorylated and becomes associated with Smad4, the common Smad, and the resulting complex translocates to the nucleus to regulate transcription. DLX1 is the product of a member of the distal-less homeobox gene famil ...[more]