Dataset Information

Prognostic impact of CD168 expression in gastric cancer.

ABSTRACT:

Background

Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to promote tumor progression and metastases. Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear.

Methods

We examined the CD168 expression of 196 consecutive gastric cancer patients by immunohistochemistry. According to CD168 positivity, the 196 gastric cancer patients were divided into two groups (57 CD168-positive and 139 CD168-negative patients). The correlation between CD168 expression and clinicopathological factors (age, sex, histology, tumor depth, lymph node status, and vessel invasion) was evaluated according to the Japanese Classification of Gastric Carcinoma.

Results

Cancerous CD168 expression was detectable in 57 of the 196 tumors (29%). CD168 positivity was significantly correlated with the depth of invasion, nodal involvement, and vessel invasion (p < 0.01). Survival analysis of the 196 gastric cancer patients showed that the CD168-positive group had a significantly higher mortality than the CD168-negative group (p < 0.01). In terms of a correlation with CD168 positivity at separate clinical stages, a significance difference was only found in stages II and III. Multivariate analysis revealed that CD168 expression was a significant independent prognostic marker (p = 0.013) after depth of invasion (p < 0.005) and nodal involvement (p < 0.01).

Conclusion

Our results suggest that cancerous CD168 positivity is strongly related to the invasion and metastasis of gastric cancer tumors. These results suggest that cancerous CD168 expression can be used as a prognostic marker of gastric cancer owing to its interactions with stromal hyaluronic acid.

SUBMITTER: Ishigami S

PROVIDER: S-EPMC3076262 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Publications

Prognostic impact of CD168 expression in gastric cancer.

Ishigami Sumiya S Ueno Shinichi S Nishizono Yuka Y Matsumoto Masataka M Kurahara Hiroshi H Arigami Takaaki T Uchikado Yasuto Y Setoyama Tetsuro T Arima Hideo H Yoshiaki Kita K Kijima Yuko Y Kitazono Masaki M Natsugoe Shoji S

BMC cancer 20110324

<h4>Background</h4>Interactions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to promote tumor progression and metastases. Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear.<h4>Methods</h4>We examined the CD168 ex ...[more]

PMID: 21435222

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Dataset Information

Prognostic impact of CD168 expression in gastric cancer.

Background

Methods

Results

Conclusion

Publications

Prognostic impact of CD168 expression in gastric cancer.

Similar Datasets

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