Ontology highlight
ABSTRACT:
SUBMITTER: Zhu P
PROVIDER: S-EPMC307650 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Zhu Ping P Chertova Elena E Bess Julian J Lifson Jeffrey D JD Arthur Larry O LO Liu Jun J Taylor Kenneth A KA Roux Kenneth H KH
Proceedings of the National Academy of Sciences of the United States of America 20031210 26
We used electron tomography to directly visualize trilobed presumptive envelope (env) glycoprotein structures on the surface of negatively stained HIV type 1 (HIV-1) and simian immunodeficiency virus (SIV) virions. Wild-type HIV-1 and SIV virions had an average of 8-10 trimers per virion, consistent with predictions based on biochemical evidence. Mutant SIVs, biochemically demonstrated to contain high levels of the viral env proteins, averaged 70-79 trimers per virion in tomograms. These correla ...[more]