Ontology highlight
ABSTRACT:
SUBMITTER: Denning EJ
PROVIDER: S-EPMC3076535 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Denning Elizabeth J EJ Mackerell Alexander D AD
Journal of the American Chemical Society 20110328 15
Deoxyribonucleic acid (DNA) is composed of five major elements carbon, hydrogen, nitrogen, oxygen, and phosphorus. The substitution of any of these elements in DNA would be anticipated to have major biological implications. However, recent studies have suggested that the substitution of arsenic into DNA (As-DNA) in bacteria may be possible. To help evaluate this possibility, ab initio quantum mechanical calculations are used to show that arsenodiester and phosphodiester linkages have similar geo ...[more]