Interleukin-1beta promoter (-31T/C and -511C/T) polymorphisms in major recurrent depression.

ABSTRACT: To elucidate a genetic predisposition to major depressive disorder, we investigated two polymorphisms (-31T/C and -511C/T) in the interleukin-1beta promoter region in patients who suffered from major recurrent depression. The aim of the current work was to compare alleles and genotype layout between patients with major recurrent depression and healthy people. We would like to indicate such combination of genotypes which corresponds with major recurrent depression. Correlations between genotypes for analyzed polymorphisms and number of episodes, number of points in Hamilton Depression Rating Scale, and age of onset were investigated as well. The study group consisted of 94 patients diagnosed with major recurrent depression. The control group included 206 healthy individuals. Both groups inv

SUBMITTER: Borkowska P 

PROVIDER: S-EPMC3076565 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature