Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC307657 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Li Yi Y Welm Bryan B Podsypanina Katrina K Huang Shixia S Chamorro Mario M Zhang Xiaomei X Rowlands Tracey T Egeblad Mikala M Cowin Pam P Werb Zena Z Tan Lee K LK Rosen Jeffrey M JM Varmus Harold E HE
Proceedings of the National Academy of Sciences of the United States of America 20031210 26
Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood. Here we report that mammary tumors induced by components of the Wnt signaling pathway contain heterogeneous cell types and express early developmental markers, in contrast to tumors induced by other signaling elements. Expression of the Wnt-1 protooncogene in mammary glands of transgenic mice expands ...[more]