Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study.
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ABSTRACT:
SUBMITTER: Eskola PJ
PROVIDER: S-EPMC3076758 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study.
Eskola Pasi J PJ Kjaer Per P Daavittila Iita M IM Solovieva Svetlana S Okuloff Annaleena A Sorensen Joan S JS Wedderkopp Niels N Ala-Kokko Leena L Männikkö Minna M Karppinen Jaro I JI
International journal of molecular epidemiology and genetics 20100329 2
The objective of the present study was to examine the associations between eleven putative predisposing single nucleotide polymorphisms (COL9A3, COL11A2, IL1A, IL1B, IL6 and VDR) and early disc degeneration (DD). The population consisted of 12 to 14-year-old Danish children (N=352). DD was evaluated from magnetic resonance images (MRI). We analysed the association between DD and single nucleotide polymorphisms or haplotypes using logistic regression analyses. Of the 352 children studied, 73 boys ...[more]
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