Ontology highlight
ABSTRACT:
SUBMITTER: Munsch T
PROVIDER: S-EPMC307693 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Munsch Thomas T Freichel Marc M Flockerzi Veit V Pape Hans-Christian HC
Proceedings of the National Academy of Sciences of the United States of America 20031210 26
Neuronal dendrites have been shown to actively contribute to synaptic information transfer through the Ca2+-dependent release of neurotransmitter, although the underlying mechanisms remain elusive. This study shows that the increase in dendritic gamma-aminobutyric acid (GABA) release from thalamic interneurons mediated by the activation of 5-hydroxytryptamine type 2 receptors requires Ca2+ entry that does not involve Ca2+ release nor voltage-gated Ca2+ channels in the plasma membrane but that is ...[more]