Ontology highlight
ABSTRACT:
SUBMITTER: Liao YX
PROVIDER: S-EPMC3077042 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Organic letters 20110318 8
Sequential aldol condensation of aldehydes with methyl ketones followed by transition metal-catalyzed addition reactions of arylboronic acids to form β-substituted ketones is described. By using the 1,1'-spirobiindane-7,7'-diol (SPINOL)-based phosphite, an asymmetric version of this type of sequential reaction, with up to 92% ee, was also realized. Our study provided an efficient method to access β-substituted ketones and might lead to the development of other sequential/tandem reactions with tr ...[more]