Ontology highlight
ABSTRACT:
SUBMITTER: Butler MW
PROVIDER: S-EPMC3077063 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Butler Megan W MW Burt Amber A Edwards Todd L TL Zuchner Stephan S Scott William K WK Martin Eden R ER Vance Jeffery M JM Wang Liyong L
Annals of human genetics 20110301 2
Vitamin D and vitamin D receptor (VDR) have been postulated as environmental and genetic factors in neurodegeneration disorders including multiple sclerosis (MS), Alzheimer disease (AD), and recently Parkinson disease (PD). Given the sparse data on PD, we conducted a two-stage study to evaluate the genetic effects of VDR in PD. In the discovery stage, 30 tagSNPs in VDR were tested for association with risk as a discrete trait and age-at-onset (AAO) as a quantitative trait in 770 Caucasian PD fam ...[more]