CO2 exacerbates oxygen toxicity.
Ontology highlight
ABSTRACT:
SUBMITTER: Ezraty B
PROVIDER: S-EPMC3077260 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
CO2 exacerbates oxygen toxicity.
Ezraty Benjamin B Chabalier Maïalène M Ducret Adrien A Maisonneuve Etienne E Dukan Sam S
EMBO reports 20110225 4
Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO(2) (concentration range studied: 40-1,000 p.p.m.) increases death rates due to H(2)O(2) stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H(2)O(2)-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions ...[more]
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