Ontology highlight
ABSTRACT:
SUBMITTER: McLennan R
PROVIDER: S-EPMC3077279 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
McLennan Rebecca R Kulesa Paul M PM
Developmental dynamics : an official publication of the American Association of Anatomists 20100601 6
Cranial neural crest cells (NCCs) require neuropilin signaling to reach and invade the branchial arches. Here, we use an in vivo chick model to investigate whether the neuropilin-1 knockdown phenotype is specific to the second branchial arch (ba2), changes in NCC behaviors and phenotypic consequences, and whether neuropilins work together to facilitate entry into and invasion of ba2. We find that cranial NCCs with reduced neuropilin-1 expression displayed shorter protrusions and decreased cell b ...[more]