Ontology highlight
ABSTRACT:
SUBMITTER: Pennings JL
PROVIDER: S-EPMC3077415 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Pennings Jeroen L A JL Rodenburg Wendy W Imholz Sandra S Koster Maria P H MP van Oostrom Conny T M CT Breit Timo M TM Schielen Peter C J I PC de Vries Annemieke A
PloS one 20110414 4
<h4>Background</h4>As a first step to identify novel potential biomarkers for prenatal Down Syndrome screening, we analyzed gene expression in embryos of wild type mice and the Down Syndrome model Ts1Cje. Since current Down Syndrome screening markers are derived from placenta and fetal liver, these tissues were chosen as target.<h4>Methodology/principal findings</h4>Placenta and fetal liver at 15.5 days gestation were analyzed by microarray profiling. We confirmed increased expression of genes l ...[more]