Interactions between the immune and nervous systems in pain.
Ontology highlight
ABSTRACT:
SUBMITTER: Ren K
PROVIDER: S-EPMC3077564 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Interactions between the immune and nervous systems in pain.
Nature medicine 20101014 11
Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the transition from acute to chronic pain. In response to injury, resident immune cells are activated and blood-borne immune cells are recruited to the site of injury. Immune cells not only contribute to immune protection but also initiate the sensitization of peripheral nociceptors. Through the synthesis and release of inflammatory mediators and interactions with neurotransmitters and their receptors, the immun ...[more]
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