The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins.
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ABSTRACT:
SUBMITTER: Salomonsson E
PROVIDER: S-EPMC3077580 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins.
Salomonsson Emma E Thijssen Victor L VL Griffioen Arjan W AW Nilsson Ulf J UJ Leffler Hakon H
The Journal of biological chemistry 20110303 16
Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred- to thousand-fold higher affinity. Anginex also interacts with galectin-2, -7, -8N, ...[more]
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