Ontology highlight
ABSTRACT:
SUBMITTER: Gao C
PROVIDER: S-EPMC3077675 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Developmental dynamics : an official publication of the American Association of Anatomists 20100801 8
In the alga Chlamydomonas reinhardtii, Oda16 functions during ciliary assembly as an adaptor for intraflagellar transport of outer arm dynein. Oda16 orthologs only occur in genomes of organisms that use motile cilia; however, such cilia play multiple roles during vertebrate development and the contribution of Oda16 to their assembly remains unexplored. We demonstrate that the zebrafish Oda16 ortholog (Wdr69) is expressed in organs with motile cilia and retains a role in dynein assembly. Antisens ...[more]