Ontology highlight
ABSTRACT:
SUBMITTER: Tania N
PROVIDER: S-EPMC3077689 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Tania Nessy N Prosk Erin E Condeelis John J Edelstein-Keshet Leah L
Biophysical journal 20110401 8
Cofilin is an important regulator of actin polymerization, cell migration, and chemotaxis. Recent experimental data on mammary carcinoma cells reveal that stimulation by epidermal growth factor (EGF) generates a pool of active cofilin that results in a peak of actin filament barbed ends on the timescale of 1 min. Here, we present results of a mathematical model for the dynamics of cofilin and its transition between several pools in response to EGF stimulation. We describe the interactions of pho ...[more]