Ontology highlight
ABSTRACT:
SUBMITTER: Thomas ST
PROVIDER: S-EPMC3077731 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Thomas Suzanne T ST Yang Xinxin X Sampson Nicole S NS
Bioorganic & medicinal chemistry letters 20110306 8
The cholesterol metabolism pathway in Mycobacterium tuberculosis (M. tb) is a potential source of energy as well as secondary metabolite production that is important for survival of M. tb in the host macrophage. Oxidation and isomerization of 3β-hydroxysterols to 4-en-3-ones is requisite for sterol metabolism and the reaction is catalyzed by 3β-hydroxysteroid dehydrogenase (Rv1106c). Three series of 6-azasteroids and 4-azasteroids were employed to define the substrate preferences of M. tb 3β-hyd ...[more]