Ontology highlight
ABSTRACT:
SUBMITTER: Reeder PJ
PROVIDER: S-EPMC3077829 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Reeder Philippa J PJ Huang Yao-Ming YM Dordick Jonathan S JS Bystroff Christopher C
Biochemistry 20101203 51
The sequential order of secondary structural elements in proteins affects the folding and activity to an unknown extent. To test the dependence on sequential connectivity, we reconnected secondary structural elements by their solvent-exposed ends, permuting their sequential order, called "rewiring". This new protein design strategy changes the topology of the backbone without changing the core side chain packing arrangement. While circular and noncircular permutations have been observed in prote ...[more]