Pyrrole-based scaffolds for turn mimics.
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ABSTRACT:
SUBMITTER: Ko E
PROVIDER: S-EPMC3077957 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Two amino acid derived synthons were combined to give homopropargylic amines 2. Platinum dichloride was used to cyclize these intermediates into pyrroles 3 which collapsed to the target secondary structure mimics 1 on treatment with base. Side chains of these compounds overlay with an idealized type 1 β-turn and with an inverse γ-turn. ...[more]
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