Ontology highlight
ABSTRACT:
SUBMITTER: Brustad EM
PROVIDER: S-EPMC3080047 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Brustad Eric M EM Arnold Frances H FH
Current opinion in chemical biology 20101223 2
Developing technologies such as unnatural amino acid mutagenesis, non-natural cofactor engineering, and computational design are generating proteins with novel functions; these proteins, however, often do not reach performance targets and would benefit from further optimization. Evolutionary methods can complement these approaches: recent work combining unnatural amino acid mutagenesis and phage selection has created useful proteins of novel composition. Weak initial activity in a computationall ...[more]