Ontology highlight
ABSTRACT:
SUBMITTER: Sun PL
PROVIDER: S-EPMC3080156 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Sun Pei Long PL Lv Shu Xia SX Zhou Jian Hua JH Liu Xin Qi XQ
Acta crystallographica. Section F, Structural biology and crystallization communications 20110325 Pt 4
Like human immunodeficiency virus (HIV), equine infectious anaemia virus (EIAV) belongs to the lentivirus genus. The first successful lentiviral vaccine was developed for EIAV. Thus, EIAV may serve as a valuable model for HIV vaccine research. EIAV glycoprotein 45 (gp45) plays a similar role to gp41 in HIV by mediating virus-host membrane fusion. The gp45 ectodomain was constructed according to the structure of HIV gp41, with removal of the disulfide-bond loop region. The protein was expressed i ...[more]