Ontology highlight
ABSTRACT:
SUBMITTER: Vicente-Manzanares M
PROVIDER: S-EPMC3080254 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Vicente-Manzanares Miguel M Newell-Litwa Karen K Bachir Alexia I AI Whitmore Leanna A LA Horwitz Alan Rick AR
The Journal of cell biology 20110411 2
Migratory front-back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) on adhesive signaling. We demonstrate here that, during polarization, MIIA and MIIB coordinately promote localized actomyosin bundling, which generates large, stable adhesions that do not signal to Rac and thereby form the cell rear. MIIA formed dynamic actomyosin proto-bundles that mark the cell rear during spreading; it also bound to actin filament bundles associated with initial adhesion matu ...[more]