Adaptations to climate-mediated selective pressures in humans.
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ABSTRACT:
SUBMITTER: Hancock AM
PROVIDER: S-EPMC3080864 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Adaptations to climate-mediated selective pressures in humans.
Hancock Angela M AM Witonsky David B DB Alkorta-Aranburu Gorka G Beall Cynthia M CM Gebremedhin Amha A Sukernik Rem R Utermann Gerd G Pritchard Jonathan K JK Coop Graham G Di Rienzo Anna A
PLoS genetics 20110421 4
Humans inhabit a remarkably diverse range of environments, and adaptation through natural selection has likely played a central role in the capacity to survive and thrive in extreme climates. Unlike numerous studies that used only population genetic data to search for evidence of selection, here we scan the human genome for selection signals by identifying the SNPs with the strongest correlations between allele frequencies and climate across 61 worldwide populations. We find a striking enrichmen ...[more]
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