Ontology highlight
ABSTRACT:
SUBMITTER: Brown KC
PROVIDER: S-EPMC3080897 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Brown Kevin C KC Patterson Kristine B KB Malone Stephanie A SA Shaheen Nicholas J NJ Prince Heather M Asher HM Dumond Julie B JB Spacek Melissa B MB Heidt Paris E PE Cohen Myron S MS Kashuba Angela D M AD
The Journal of infectious diseases 20110501 10
<h4>Background</h4>Antiretroviral pharmacology in seminal plasma (SP) and rectal tissue (RT) may provide insight into antiretroviral resistance and the prevention of sexual transmission of human immunodeficiency virus (HIV). Saliva may be of utility for noninvasively measuring adherence.<h4>Methods</h4>A pharmacokinetic study was performed in 12 HIV-negative men receiving maraviroc 300 mg twice daily for 8 days. Seven time-matched pairs of blood plasma (BP) and saliva samples were collected over ...[more]