Ontology highlight
ABSTRACT:
SUBMITTER: Radiloff DR
PROVIDER: S-EPMC3081012 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Radiloff Daniel R DR Wakeman Timothy P TP Feng Junjie J Schilling Stephen S Seto Edward E Wang Xiao-Fan XF
Proceedings of the National Academy of Sciences of the United States of America 20110330 16
Senescence is a cellular stress response characterized by persistent cell growth arrest under various stress conditions, including oncogene activation or tumor suppressor loss, which functions as a critical barrier that must be overcome to allow the progression from a precancerous or preinvasive lesion to a malignant tumor. Trefoil factor 1 (TFF1) is a secreted protein involved in maintaining the gastrointestinal epithelium by serving a tumor-suppressive role; however, TFF1 is overexpressed in s ...[more]