Ontology highlight
ABSTRACT:
SUBMITTER: Hoermann G
PROVIDER: S-EPMC3081146 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Hoermann Gregor G Cerny-Reiterer Sabine S Perné Andrea A Klauser Miriam M Hoetzenecker Konrad K Klein Katharina K Müllauer Leonhard L Gröger Marion M Nijman Sebastian M B SM Klepetko Walter W Valent Peter P Mayerhofer Matthias M
The American journal of pathology 20110331 5
Systemic mastocytosis is a neoplastic disease of mast cells harboring the activating KIT mutation D816V. In most patients, mast cell infiltration in the bone marrow is accompanied by marked microenvironment alterations, including increased angiogenesis, osteosclerosis, and sometimes fibrosis. Little is known about the mast cell-derived molecules contributing to these bone marrow alterations. We show here that neoplastic mast cells in patients with systemic mastocytosis express oncostatin M (OSM) ...[more]