Ontology highlight
ABSTRACT:
SUBMITTER: Licciulli S
PROVIDER: S-EPMC3081152 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Licciulli Silvia S Luise Chiara C Scafetta Gaia G Capra Maria M Giardina Giuseppina G Nuciforo Paolo P Bosari Silvano S Viale Giuseppe G Mazzarol Giovanni G Tonelli Chiara C Lanfrancone Luisa L Alcalay Myriam M
The American journal of pathology 20110501 5
Cellular senescence has been widely recognized as a tumor suppressing mechanism that acts as a barrier to cancer development after oncogenic stimuli. A prominent in vivo model of the senescence barrier is represented by nevi, which are composed of melanocytes that, after an initial phase of proliferation induced by activated oncogenes (most commonly BRAF), are blocked in a state of cellular senescence. Transformation to melanoma occurs when genes involved in controlling senescence are mutated or ...[more]