Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.
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ABSTRACT:
SUBMITTER: Hawthorn L
PROVIDER: S-EPMC3081321 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.
Hawthorn Lesleyann L Cowell John K JK
PloS one 20110422 4
Wilms tumor (WT) has been a model to study kidney embryogenesis and tumorigenesis and, although associated with hereditary, cancer predisposition syndromes, the majority of tumors occur sporadically. To analyze genetic changes in WT we have defined copy number changes and loss of heterozygosity in 56 Wilms tumors using high resolution oligonucleotide arrays at a average resolution of ~12 Kb. Consistent deletions were seen on chromosomes 1p, 4q, 7p, 9q, 11p, 11q, 14q, 16q, and 21q. High frequency ...[more]
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