Ontology highlight
ABSTRACT:
SUBMITTER: Tran ED
PROVIDER: S-EPMC3081385 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Tran Edward D ED Yang Ming M Chen Andrew A Delano Frank A FA Murfee Walter L WL Schmid-Schönbein Geert W GW
Microcirculation (New York, N.Y. : 1994) 20110401 3
A complication of the spontaneously hypertensive rat (SHR) is microvascular rarefaction, defined by the loss of microvessels. However, the molecular mechanisms involved in this process remain incompletely identified. Recent work in our laboratory suggests that matrix metalloproteinases (MMPs) may play a role by cleavage of the vascular endothelial growth factor receptor 2 (VEGFR-2). In order to further delineate the role for MMPs in microvascular rarefaction, the objective of the current study w ...[more]