Ontology highlight
ABSTRACT:
SUBMITTER: Moleirinho A
PROVIDER: S-EPMC3081807 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20110425 4
Metallothioneins (MT) are small proteins involved in heavy metal detoxification and protection against oxidative stress and cancer. The mammalian MT family originated through a series of duplication events which generated four major genes (MT1 to MT4). MT1 and MT2 encode for ubiquitous proteins, while MT3 and MT4 evolved to accomplish specific roles in brain and epithelium, respectively. Herein, phylogenetic, transcriptional and polymorphic analyses are carried out to expose gains, losses and di ...[more]