Ontology highlight
ABSTRACT:
SUBMITTER: Zou MF
PROVIDER: S-EPMC3081927 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Zou Mu-Fa MF Cao Jianjing J Rodriguez Alice L AL Conn P Jeffrey PJ Newman Amy Hauck AH
Bioorganic & medicinal chemistry letters 20101228 9
Based on SAR in the alkyne class of mGlu5 receptor negative allosteric modulators and a set of amide-based positive allosteric modulators, optimized substitution of the aryl 'b' ring was used to create substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides. Results from an mGlu5 receptor functional assay, using calcium fluorescence, revealed varying efficacies and potencies that provide evidence that subtle changes in compounds within a close structural class can have marked effects on functiona ...[more]