Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus.
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ABSTRACT:
SUBMITTER: Andrianasolo EH
PROVIDER: S-EPMC3081957 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus.
Andrianasolo Eric H EH Haramaty Liti L McPhail Kerry L KL White Eileen E Vetriani Costantino C Falkowski Paul P Lutz Richard R
Journal of natural products 20110111 4
Two ceramide derivatives, bathymodiolamides A (1) and B (2), were isolated from the deep-sea hydrothermal vent invertebrate mussel Bathymodiolus thermophilus. The molecular structures of these compounds were determined using a combination of NMR spectroscopy, mass spectrometry, and chemical degradation. Biological activities were assessed in a ApopScreen cell-based screen for apoptosis induction and potential anticancer activity. To our knowledge, this is the first report of secondary metabolite ...[more]
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