Ontology highlight
ABSTRACT:
SUBMITTER: Getnet D
PROVIDER: S-EPMC3082355 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20090401 8
Tumors express a wide variety of both mutated and nonmutated Ags. Whether these tumor Ags are broadly recognized as self or foreign by the immune system is currently unclear. Using an autochthonous prostate cancer model in which hemagglutinin (HA) is specifically expressed in the tumor (ProHA x TRAMP mice), as well as an analogous model wherein HA is expressed in normal tissues as a model self-Ag (C3HA(high)), we examined the transcriptional profile of CD4 T cells undergoing Ag-specific division ...[more]