Dataset Information

The GeneInsight Suite: a platform to support laboratory and provider use of DNA-based genetic testing.

ABSTRACT: The future of personalized medicine will hinge on effective management of patient genetic profiles. Molecular diagnostic testing laboratories need to track knowledge surrounding an increasingly large number of genetic variants, incorporate this knowledge into interpretative reports, and keep ordering clinicians up to date as this knowledge evolves. Treating clinicians need to track which variants have been identified in each of their patients along with the significance of these variants. The GeneInsight(SM) Suite assists in these areas. The suite also provides a basis for interconnecting laboratories and clinicians in a manner that increases the scalability of personalized medicine processes.

SUBMITTER: Aronson SJ

PROVIDER: S-EPMC3082613 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Publications

The GeneInsight Suite: a platform to support laboratory and provider use of DNA-based genetic testing.

Aronson Samuel J SJ Clark Eugene H EH Babb Lawrence J LJ Baxter Samantha S Farwell Lisa M LM Funke Birgit H BH Hernandez Amy Lovelette AL Joshi Victoria A VA Lyon Elaine E Parthum Andrew R AR Russell Franklin J FJ Varugheese Matthew M Venman Thomas C TC Rehm Heidi L HL

Human mutation 20110322 5

The future of personalized medicine will hinge on effective management of patient genetic profiles. Molecular diagnostic testing laboratories need to track knowledge surrounding an increasingly large number of genetic variants, incorporate this knowledge into interpretative reports, and keep ordering clinicians up to date as this knowledge evolves. Treating clinicians need to track which variants have been identified in each of their patients along with the significance of these variants. The Ge ...[more]

PMID: 21432942

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Project description:BackgroundInfluenza A Virus (IAV) causes respiratory disease in swine and is a zoonotic pathogen. Uncontrolled IAV in swine herds not only affects animal health, it also impacts production through increased costs associated with treatment and prevention efforts. The Iowa State University Veterinary Diagnostic Laboratory (ISU VDL) diagnoses influenza respiratory disease in swine and provides epidemiological analyses on samples submitted by veterinarians.DescriptionTo assess the incidence of IAV in swine and inform stakeholders, the ISU FLUture website was developed as an interactive visualization tool that allows the exploration of the ISU VDL swine IAV aggregate data in the clinical diagnostic database. The information associated with diagnostic cases has varying levels of completeness and is anonymous, but minimally contains: sample collection date, specimen type, and IAV subtype. Many IAV positive samples are sequenced, and in these cases, the hemagglutinin (HA) sequence and genetic classification are completed. These data are collected and presented on ISU FLUture in near real-time, and more than 6,000 IAV positive diagnostic cases and their epidemiological and evolutionary information since 2003 are presented to date. The database and web interface provides rapid and unique insight into the trends of IAV derived from both large- and small-scale swine farms across the United States of America.ConclusionISU FLUture provides a suite of web-based tools to allow stakeholders to search for trends and correlations in IAV case metadata in swine from the ISU VDL. Since the database infrastructure is updated in near real-time and is integrated within a high-volume veterinary diagnostic laboratory, earlier detection is now possible for emerging IAV in swine that subsequently cause vaccination and control challenges. The access to real-time swine IAV data provides a link with the national USDA swine IAV surveillance system and allows veterinarians to make objective decisions regarding the management and control of IAV in swine. The website is publicly accessible at http://influenza.cvm.iastate.edu .

Dataset Information

The GeneInsight Suite: a platform to support laboratory and provider use of DNA-based genetic testing.

Publications

The GeneInsight Suite: a platform to support laboratory and provider use of DNA-based genetic testing.

Similar Datasets

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