Ontology highlight
ABSTRACT:
SUBMITTER: Altarescu G
PROVIDER: S-EPMC3082663 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Altarescu Gheona G Reish Orit O Renbaum Paul P Kasterstein Ester E Komarovsky Dvorah D Komsky Alisa A Bern Orna O Strassburger Dvorah D Levy-Lahad Ephrat E Ron-El Raphael R
Journal of assisted reproduction and genetics 20101201 3
<h4>Purpose</h4>Development of a molecular PGD protocol for a male with an X-linked deletion in the SHOX gene region, located in the pseudoautosomal region of the X/Y chromosomes. Due to excessive recombination in this region, the deletion can be found in male offspring.<h4>Methods</h4>We developed a 13 marker multiplex fluorescent PCR protocol: 3 markers within the deleted SHOX region, 5 flanking markers, 3 informative markers on chromosome 21 (advanced maternal age) and 2 markers for sex deter ...[more]