Ontology highlight
ABSTRACT:
SUBMITTER: Plant LD
PROVIDER: S-EPMC3082930 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Plant Leigh D LD Dowdell Evan J EJ Dementieva Irina S IS Marks Jeremy D JD Goldstein Steve A N SA
The Journal of general physiology 20110501 5
Voltage-gated Kv2.1 potassium channels are important in the brain for determining activity-dependent excitability. Small ubiquitin-like modifier proteins (SUMOs) regulate function through reversible, enzyme-mediated conjugation to target lysine(s). Here, sumoylation of Kv2.1 in hippocampal neurons is shown to regulate firing by shifting the half-maximal activation voltage (V(1/2)) of channels up to 35 mV. Native SUMO and Kv2.1 are shown to interact within and outside channel clusters at the neur ...[more]