Ontology highlight
ABSTRACT:
SUBMITTER: He J
PROVIDER: S-EPMC3083299 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
He Jin J Nguyen Anh Tram AT Zhang Yi Y
Blood 20110210 14
The histone H3 lysine 36 dimethyl-specific demethylase KDM2b/JHDM1b, which is highly expressed in various human leukemias, was previously found to be important in regulating cell proliferation and cellular senescence. However, its functions in leukemia development and maintenance are unclear. Here, we demonstrate that ectopic expression of Kdm2b/Jhdm1b is sufficient to transform hematopoietic progenitors. Conversely, depletion of Kdm2b/Jhdm1b in hematopoietic progenitors significantly impairs Ho ...[more]