Ontology highlight
ABSTRACT:
SUBMITTER: Chen F
PROVIDER: S-EPMC3083454 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Chen Fujun F Liu Yun Y Sugiura Yoshie Y Allen Paul D PD Gregg Ronald G RG Lin Weichun W
Nature neuroscience 20110327 5
Developing skeletal myofibers in vertebrates are intrinsically 'pre-patterned' for motor nerve innervation. However, the intrinsic factors that regulate muscle pre-patterning remain unknown. We found that a functional skeletal muscle dihydropyridine receptor (DHPR, the L-type Ca(2+) channel in muscle) was required for muscle pre-patterning during the development of the neuromuscular junction (NMJ). Targeted deletion of the β1 subunit of DHPR (Cacnb1) in mice led to muscle pre-patterning defects, ...[more]