Ontology highlight
ABSTRACT:
SUBMITTER: Savoldo B
PROVIDER: S-EPMC3083795 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Savoldo Barbara B Ramos Carlos Almeida CA Liu Enli E Mims Martha P MP Keating Michael J MJ Carrum George G Kamble Rammurti T RT Bollard Catherine M CM Gee Adrian P AP Mei Zhuyong Z Liu Hao H Grilley Bambi B Rooney Cliona M CM Heslop Helen E HE Brenner Malcolm K MK Dotti Gianpietro G
The Journal of clinical investigation 20110411 5
Targeted T cell immunotherapies using engineered T lymphocytes expressing tumor-directed chimeric antigen receptors (CARs) are designed to benefit patients with cancer. Although incorporation of costimulatory endodomains within these CARs increases the proliferation of CAR-redirected T lymphocytes, it has proven difficult to draw definitive conclusions about the specific effects of costimulatory endodomains on the expansion, persistence, and antitumor effectiveness of CAR-redirected T cells in h ...[more]